Posted on:August 13, 2025

Sr. Mechanical Engineer, Fluidics/Perfusion at Until

Until is hiring a Sr. Mechanical Engineer, Fluidics/Perfusion in San Francisco, CA, US. On-site. Pay: USD 150k-210k/yr.

About Until

Until is developing reversible cryopreservation technology to preserve donated human organs at subzero temperatures without ice formation, then rewarm them for transplantation. The company aims to solve the donor organ procurement and matching problem, and is working toward whole-body reversible cryopreservation as a longer-term goal.

Sr. Mechanical Engineer, Fluidics/Perfusion job description

Until is a moonshot company building a “pause button” for biology. Our near-term focus is organ-scale reversible cryopreservation: preserving donated organs at subzero temperatures without ice formation, then rewarming them uniformly for transplant. By solving this grand challenge, we’re laying the foundation for whole-body reversible cryopreservation, giving patients a bridge to future cures.
 
To achieve our goal, we are assembling an interdisciplinary team to develop perfusion systems, cryoprotectant formulations, and vitrification and rewarming hardware.
 
We envision a future where no transplantable organ is lost to logistics, and no terminal diagnosis is final because patients can safely wait for future medicine to arrive.
 
About the Role
Accomplishing our mission requires skilled engineers pushing the boundary developing new systems for heat and mass transfer in N-of-1 perfusion and heat exchange devices. We're building a fast-paced, scrappy team of engineers to create technology indistinguishable from magic.
 

About You

  • Track record of exceptional engineering abilities
  • Experience leading highly technical, multidisciplinary teams
  • 3+ years experience/graduate level in Mechanical Engineering, Physics, or equivalent
  • Deep understanding of heat and mass transfer principles alongside fluidic design experience
  • High degree of autonomy across full engineering stack: electromechanical design and fabrication, control software, physical modeling
  • Desire to join a fast-paced, scrappy engineering team
  • Preferred Qualifications

  • Experience with organ perfusion in a research or clinical context
  • Experience working in a startup
  • Benefits

  • Opportunity for outsized impact creating the future as an early team member
  • Generous medical, dental and vision insurance coverage for employees and their dependents
  • Flexible time off and paid holidays
  • Competitive compensation package, including salary and equity
  • Access to a 401(k) retirement savings plan
  • FSA and commuter benefits
  • Subsidized lunch daily
  • As an equal opportunity employer, Until is committed to providing employment opportunities to all individuals. All applicants for positions at Until will be treated without regard to race, color, ethnicity, religion, sex, gender, gender identity and expression, sexual orientation, national origin, disability, age, marital status, veteran status, pregnancy, or any other basis prohibited by applicable law.

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